Talbot died in the home of George Macbeth at London, Ontario in 1853 and is interred in the cemetery of St. Peters Anglican Church near Tyrconnell, Ontario in Elgin County. When he dies in 1853, at age 82, he had been visited at his historic home on Lake Erie by General Isaac Brock, Francis Gore, Mrs. Anna Jameson, Sir Peregrine Maitland, Sir John Colborne, Chief Justice Sir John Beverley Robinson, his brother the Honourable Peter Robinson, Dr. William Dunlop, Bishops Stuart and Strachan, Sir George Arthur, the Duke of Richmond, Lord Aylmer and many others. He lies buried at Port Talbot overlooking his beloved Lake Erie.